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pentobarbital will reduce the extent or effect of quetiapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May perhaps cause lack of virologic reaction